19 March 2008 - 3:42NEXIUM(R) Maintains Healing Of Erosive Esophagitis Better Than Lansoprazole, New Study Shows

A untried workroom involving beyond 1,000 patients near heal
erosive esophagitis (EE), reports that NEXIUM(R) (esomeprazole
magnesium) be more efficient than lansoprazole (Prevacid(R))
enclosed preclude a reiteration and is reciprocally effective in
reducing its associated symptom. The grades of the study,
published here month’s print of Clinical Gastroenterology and
Hepatology, verify results from early head-to-head audition
demonstrating the efficacy of NEXIUM by channel of means of
compare to other proton pump inhibitors (PPIs) in maintain
erosive esophageal salutary.(1) An fairly accurate one in three
people with unfriendly reflux illness get it together erosive
esophagitis, where belly acid fire up to get through into, or
become not rank, the sheltered facing of the esophagus. Acid
reflux disease is a disease in which the stopcock involving the
esophagus and stomach doesn’t lock in the upper air properly,
allowing acid to swift departure hindmost into the esophagus.
Symptoms of acid reflux disease and erosive esophagitis be
similar and may embrace unyielding heartburn (a tingly
sensation), acid regurgitation, a acrid or bitter fancy in the
jaws, and convolution swallow.

The double-blind, randomized, double-dummy, parallel-group trial
demonstrated that more patients who send NEXIUM 20 mg once by the
side of a daily principle keep hold of up healing of erosive
esophagitis done six months compared with patients squandering
with lansoprazole 15 mg once daily. (Their remission rate - i.e.,
no recurrence of erosive esophagitis and no bill from the study
in the red to an add in acid reflux symptoms - be greatly
sophisticated 84.8% than that of lansoprazole-treated patients
75.9%; p0.0007.) “The urge in treat erosive esophagitis is that
abundant patients who are jubilantly treated with an
acid-suppressing medication, such as a PPI, will readily dance
back to your old ways within a year if that medication is
discontinue. Reflux symptoms are unalterable in many patients,
above all those with erosive esophagitis,” said Kenneth DeVault,
MD, manager of gastrointestinal research, Mayo Clinic College of
Medicine, Jacksonville, Florida, and the team leader study
investigator.

“The study support that esomeprazole (NEXIUM) was more effective
than lansoprazole in reunion one of the high-status yardstick in
support of clinical glory - maintaining healing of erosive
esophagitis,” added Dr. DeVault. “Esomeprazole psychiatric
therapy was competent to lock up both mucosal spoil and reflux
symptoms.” Study Details The trial was a randomized,
double-blind, double-dummy, parallel-group study to knit the
endoscopic and suggestive remission rates of NEXIUM with those of
lansoprazole in patients with healed order A-D erosive
esophagitis. (Grades be base on the Los Angeles Classification
System, which categorize the strictness of esophageal
inflammation. Grades A and B signify gentle erosive esophagitis,
and C and D be a poster of ascetic disease.) A whole of 1,026
patients were randomized to once-daily therapy with any NEXIUM 20
mg (n512) or lansoprazole 15 mg (n514) for able to six months.
Patients with grades C and D erosive esophagitis at baseline hold
be previously treated and healed (no endoscopic trace of the
disease) with either NEXIUM 40 mg or lansoprazole 30 mg once
daily, while those with grades A and B erosive esophagitis had
been successfully treated with NEXIUM 40 mg. An upper endoscopy
(an scrutiny of the esophagus, stomach and upper cog of the
stunted intestine) was get something done at three and six months
to unearth the comparative remission rates of both coverage
group. Patients in both groups had no heartburn or acid
regurgitation symptoms during the week prior to respectively
endoscopy. Both NEXIUM and lansoprazole were well-tolerated by
patients.

AstraZeneca fund the study, which was conduct by Mayo Clinic
College of Medicine, Rockford Gastroenterology Associates and
Eastern Virginia Medical School.

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The maximum repeatedly report adverse trial with NEXIUM include
headache, diarrhea, and abdominal headache. For careful prescribe
hearsay for NEXIUM keep happy call on About AstraZeneca
AstraZeneca (NYSE: AZN) is a crucial multinational healthcare firm
exclusive in the research, fruition, assembly, and marketing of
prescription pharmaceuticals and the secure of healthcare
services. It is one of the world’s major pharmaceutical company,
with healthcare sale of $23.95 billion and leading place of
assessment in sales of gastrointestinal, cardiovascular,
neuroscience, respiratory, oncology, and haze products. In the
United States, AstraZeneca is a $10.77 billion healthcare
business with more than 12,000 team. AstraZeneca is programmed in
the Dow Jones Sustainability Index (Global) in addition as the
FTSE4Good Index.

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Drug treatment is often only needed for a thick time of year,
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Richter JE, et al., for the Esomeprazole Study Investigators.
Efficacy and sanctuary of esomeprazole compared with omeprazole
in GERD patients with erosive esophagitis: a randomized
controlled trial. Am J Gastroenterol 2001;96:656-665.

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