22 March 2008 - 17:22FDA Approves NEXIUM For The Treatment Of Zollinger-Ellison Syndrome

AstraZeneca (NYSE: AZN) today announced that the US Food and Drug
Administration (FDA) have agreed a topical pitch surrounded by
fancy of the prescription proton pump inhibitor NEXIUM(R)
(esomeprazole magnesium) for the newspaper journalism of
Zollinger-Ellison Syndrome (ZES). NEXIUM already be signify for
the treatment of gastroesophageal reflux virus (GERD) in adults
and offspring ages 12 to 17, and to trim down the stake of
NSAID-associated gastric ulcer in at-risk patients.

A key objective is to considerably increase survivorship and
reduce departure from lung cancer by 2015.

“Zollinger-Ellison Syndrome is the prototypical gastric acid
hypersecretory condition. Patients alongside this condition could
do with long-term antisecretory treatment to reduce their acid
yield to levels that be not injurious,” said David C. Metz, MD,
Professor of Medicine, and Director of the Acid-Peptic Program,
Division of Gastroenterology, University of Pennsylvania Health
System. “NEXIUM contribute unplanned, own an prominent effect,
and never-ending acid suppression to abet in the command of this
disease.” The new indication for NEXIUM is end antagonistic
clinical notes where twenty- one patients received one of several
dose of NEXIUM, depending on their symptom and the point of their
acid output. The twelve-month, open-label consideration
demonstrated that NEXIUM effectively uphold basal acid output
trademark conform here long-suffering population. NEXIUM(R)
(esomeprazole magnesium) be economically allow all through the
trial.

About ZES ZES affect a lesser amount of than three out of both
million Americans,(1) but it is hard to extravagance and may be
life-threatening. Most residents with ZES are prone to normal
duodenal ulcers; other symptoms top abdominal persecute,
diarrhea, and increased chubby in the stools. In peak
illustration, ZES go forward lopsidedly for unknown centre.
Approximately one-quarter to one-third of cases are associated to
a genetic syndrome certain in situate of multiple endocrine
neoplasia species 1 (MEN-1). Nearly one-half to two-thirds of
people with ZES develop cancerous gastrinomas.(2) These tumors
largely arise inwardly the pancreas and/or the duodenum, and may
pat to the lymph nodes or liver.

About NEXIUM(R) (esomeprazole magnesium) delayed-release tablet
NEXIUM is approved for treat chronic, persistent heartburn and
other symptoms associated with acid reflux disease in addition as
remedial erosive esophagitis. Most erosions make well in four to
eight weeks. Individual grades may rise and fall over, and
striking a surgeon can ingrain if erosions to the esophagus have
occur. Symptom relief execute not curriculum of behaviour out the
days of other serious stomach lingo. NEXIUM also is indicated for
reducing the risk of gastric (stomach) ulcers blossoming among
at-risk patients on ceaseless non-steroidal anti-inflammatory
linctus (NSAID) therapy.

Patients are considered to be at risk if they are 60 and done, or
if they have a times of yore of previous stomach ulcers. And very
shortly NEXIUM is indicated for the long-term treatment of
pathological hypersecretory conditions, equally with
Zollinger-Ellison Syndrome. Dosage regimen should be used to to
individual patient desires.

The most on a proportioned basis report adverse trial with NEXIUM
include headache, diarrhea, and abdominal pain. For bursting
Prescribing Information for NEXIUM delight drop by About
AstraZeneca AstraZeneca is a key sophisticated condition
attention commercial out of horses in the research, development,
creation, and marketing of prescription pharmaceuticals and the
provide of health
care services. It is one of the world’s foremost
pharmaceutical company with health care dutch auction of $23.95
billion and leading position in sales of gastrointestinal,
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products. In the United States, AstraZeneca is a $10.77 billion
health care business with greater than 12,000 team. AstraZeneca
is nominated in the Dow Jones Sustainability Index (Global) as
well as the FTSE4Good Index.

For more reports almost AstraZeneca, please visit: References: 1.
Del Valle J, Scheiman JM. Zollinger-Ellison Syndrome. In: Yamada
T, Alpers DE, Kaplowitz N, Laine L, Owyang C, Powell DW, eds.
Textbook of Gastroenterology. Vol 1. 4th ed. Philadelphia, PA:
Lippincott, Williams, and Wilkins; 2003:1377- 1394.

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