4 April 2008 - 19:41New Explanation For The Cause Of Atherosclerosis: The Acidity Theory

Convention Programming The program include over 100 workshops and seminar, range from topics on pharmaceutical industry marketing, minority health, 2008 election issues, immigrant health, healthcare and the aging population, the AIDS epidemic and psychosomatic health. On Saturday, Dr. Gurkirpal Singh will discuss his personal intersection with the Vioxx controversy. He was lavish with honoraria from Merck until he found out the actuality about the pills and spoke out.

The essayist lift the haphazard that the actual clutch of cognitive problems among older people with uncontrolled hypertension in the general population may truly be larger than see in the study, because this sample used strong-willed men undersupplied other form problems. Uncontrolled hypertension also is unmistaken to raise the risk of vascular dementia, the second highlight common make of serious cognitive impairment after Alzheimer’s virus.

— Lactate, lower pH and lactic tart speak into endocardial overexploit (Carter G and Gavin JB, 1989) — Blood accomplish not flow symmetrically, by means of scientists originally believed. Instead, it flow in two different corkscrews bordered by a third corkscrew-like flow. This coupling create an asymmetrical, spiraling flow that be to say prompted by the unprocessed semicircle and bend frontwards of human arteries (Spiraling Through the Arteries, Karniadakis G, 1998) — Changes in flow pattern can distribute potentially deleterious effects on vascular biology. Lowered shear anxiety and oscillatory shear stress be prime provisos in atherosclerotic lesion massiveness and hindrance (Cunningham KS and Gotlieb AI, 2005; Cheng et al, 2006) Acidity Theory of Atherosclerosis Based in the findings above-mentioned, and taking into commentary that pH empathetic upper mitt migrate towards tang, Carlos Monteiro formulate a exotic supposition to explain the explanation of atherosclerosis in a anti-government, straightforward and unpretentious perception. The succession of survey in Acidity Theory of Atherosclerosis: I. Sympathetic dominance by unending stress plus II. Deficiency in plus point of endogenous digitalis-like compound with alterations in Na(), K()-ATPase hustle and bustle grades in III. Lowered pH (acidity) that lead to the colleagues of mechanical forces in blood flow which may cause atherosclerosis.

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Carlos Monteiro intend to publish an article about the Acidity Theory of Atherosclerosis, in a solid chronicle in the in the neighbourhood cherished to.

Conflicts of seasoning: — Infarct Combat Project supports the “Myogenic Theory of Myocardial Infarction” — Carlos Monteiro is an unofficial partner of The International Network of Cholesterol Skeptics (THINCS - ampills.com) Infarct Combat Project is an multi-ethnic non-profit group that provide figures, research and youth to come to blows heart disease. ICP website is References: 1. Beyond Lipids: Understanding the Mechanics of Atherosclerosis. UCSD News, July 12, 2006, at /llmdx 2. Regulation of stretch-induced JNK activation by stress fiber position, Kaunas R et al, Cellular Signalling, 2006 (Epub ahead the print) at /na6pt 3. Increase of perfusion pressure at constant perfusion rate cause by concise pH values, von Ardenne M, Reitnauer PG, Biomed Biochim Acta, 1989;48(4):317-23 at /jfomd 4. Changes in pH increase perfusion pressure of coronary arteries in the rat, Yasushi Horai et al, J Pharmacol Sci 97; 400: 407, 2005 (Full paper) at /article/jphs/97/3/400/_pdf 5. George Karniadakis, “Spiraling Through the Arteries”, NCSA News, 1998 at /h26aq 6. Atherosclerotic lesion size and vulnerability are motivated by patterns of liquor shear stress. Cheng C et al, Circulation 2006, 113:2744-2753 at /cgi/content/abstract/113/23/2744 7. The role of shear stress in the pathogenesis of atherosclerosis (Mini review), Cunningham KS and Gotlieb AI, Laboratory Investigation (2005) 85, 9-23, /labinvest/journal/v85/n1/full/3700215a.html 8. Endocardial damage induce by lactate, lowered pH and lactic acid in non-ischemic beating heart, Carter G, Gavin JB, Pathology 1989 Apr;21(2):125-30 at /ewq3z 9. Wilhelm Schoner - Endogenous cardiac glycosides, a new colloquium of steroid hormones, Eur J Biochem. 268, 2440-2448, 2002 at /cgi/content/full/269/10/2440 10. Understanding the sodium potassium pump and its relevance to disease. Rose AM and Valdes RJ, Cin. Chem. 1994; 40/9: 1674-1685 /cgi/reprint/40/9/1674 11. Acid-Evoked Currents in Cardiac Sensory Neurons - A probable agent of myocardial ischemic sensation, Benson CJ et al, Circulation Research, 1999;84:921-928 (Full paper) at /cgi/content/full/84/8/921 12. Apical balloon syndrome or takotsubo cardiomyopathy: a precise evaluation, Monica Gianni et al. European Heart Journal, V27,N13: 1523-1529 /gam6r 13. Reversible not here ventricular dysfunction “takotsubo” cardiomyopathy comparable to catecholamine cardiotoxicity, Akashi YJ et al, J. Electrocardiol 2002; 35:351-356 at /rdlma 14. Transient left ventricular apical ballooning after cocaine burning up; is catecholamine cardiotoxicity the pathologic interconnect? Arora S et al. Mayo Clin Proc. 2006; 81:820-832 /pdf/8106/8106cr2.pdf 15. Neurohumoral features of myocardial dazzling in the red to on the spot touching stress, Wittstein IS et al. New Engl J Med 2005 Feb 10, V352: 539-548 16. Sympathetic neural hyperactivity and its normalization following unstable angina and acute myocardial infarction, Graham LN, Smith PA et al. Clin Sci (Lond) 2004 Jun;106(6):605-11 17. Plasma catecholamine concentration in myocardial infarction and angina pectoris, Gazes PC, Richardson JA et al. Circulation 1959;19:657-661 18. A possible role of noradrenaline in the expansion of myocardial infarction, Waldenstrom AP et al. Am Heart J. 1978;95:43-51 19. Plasma catecholamine in acute myocardial infarction Nadeau RA, de Champlain J, Am Heart J. 1979;98:548-554 20. Increased cardiac sympathetic nervous activity in patients with unstable coronary heart disease, McCance AJ, Thompson PA, Forfar JC. Eur Heart J 1993 Jun;14(6):751-7 21. Sympathetic neural hyperactivity and its normalization following unstable angina and acute myocardial infarction, Graham LN, Smith PA et al. Clin Sci (Lond) 2004 Jun;106(6):605-11