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17 May 2008 - 8:45America’s Weight Problem - Where Is The Pharmaceutical Industry? Part 6

By George M. Ekema, Ph.D.Drug Discovery Scientist, Alexa Biotherapeutics, Inc.

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2. - Kojima, M. et al. Ghrelin is a growth-hormone-releasing acylated peptide from belly. Nature 402, 656-60 (1999).

ARTICLE: G O’Connor et al. Acute respiratory robustness effects of air smoke in opposition asthmatic offspring surrounded by US cloak-and-dagger city. Journal of Allergy and Clinical Immunology (2008).

4. - Tatemoto, K., Carlquist, M. & Mutt, V. Neuropeptide Y–a revolutionary wits peptide beside structural equivalence to peptide YY and pancreatic polypeptide. Nature 296, 659-60 (1982).

5. - Harris, J.I. & Lerner, A.B. Amino-acid sparkle of the alpha-melanocyte-stimulating hormone. Nature 179, 1346-7 (1957).

6. - Carraway, R. & Leeman, S.E. The amino rancorous sequence of a hypothalamic peptide, neurotensin. J Biol Chem 250, 1907-11 (1975).

7. - Patzelt, C. & Schiltz, E. Conversion of proglucagon in pancreatic alpha cell: the top endproducts be glucagon and a single-handed peptide, the major proglucagon particle, that hide from view two glucagon-like sequence. Proc Natl Acad Sci U S A 81, 5007-11 (1984).

3. Idiopathic. As in essential hypertension. “Essential” is a hallowed term target “We don’t know the rationale.” Exogenous: Originating from masquerade the organism. Insulin taken by a diabetic is exogenous insulin.

9. - Soucy, J. & Leblanc, J. Protein meal and postprandial thermogenesis. Physiol Behav 65, 705-9 (1999).

10. - Johnston, C.S., Day, C.S. & Swan, P.D. Postprandial thermogenesis is increased 100% against a high-protein, low-calorie diet versus a high-carbohydrate, low-fat diet in vigorous, infantile women. J Am Coll Nutr 21, 55-61 (2002).

11. - MacDougald, O.A., Hwang, C.S., Fan, H. & Lane, M.D. Regulated expression of the obese gene products (leptin) in white adipose tissue and 3T3-L1 adipocytes. Proc Natl Acad Sci U S A 92, 9034-7 (1995).

12. - Mizuno, T.M., Makimura, H. & Mobbs, C.V. The physiological manoeuvre of the agouti-related peptide gene: the domination of weight and metabolic rate. Ann Med 35, 425-33 (2003).

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